Type of evidence that this mRNA is a target of HuR:
binding to target RNA
effect on reporter construct
effect on target at protein level
effect on target at RNA level
effect on target RNA stability
Type of evidence that this mRNA is a target of AUF1:
binding to target RNA
effect on reporter construct
effect on target at protein level
effect on target at RNA level
effect on target RNA stability
Publications providing the experimental evidence:
Hydrogen peroxide induces p16(INK4a) through an AUF1-dependent manner
Guo, G E, Ma, L W, Jiang, B, Yi, J, Tong, T J, Wang, W G
J Cell Biochem (2010) 109 (5) 1000-1005.
Identification of a signature motif in target mRNAs of RNA-binding protein AUF1
Mazan-Mamczarz, K, Kuwano, Y, Zhan, M, White, E J, Martindale, J L, Lal, A, Gorospe, M
Nucleic Acids Res (2009) 37 (1) 204-214.
Increased stability of the p16 mRNA with replicative senescence
Wang, W, Martindale, J L, Yang, X, Chrest, F J, Gorospe, M
EMBO Rep (2005) 6 (2) 158-164.
Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs
Lal, A, Mazan-Mamczarz, K, Kawai, T, Yang, X, Martindale, J L, Gorospe, M
EMBO J (2004) 23 (15) 3092-3102.
Identification of a target RNA motif for RNA-binding protein HuR
López de Silanes, I, Zhan, M, Lal, A, Yang, X, Gorospe, M
Proc Natl Acad Sci U S A (2004) 101 (9) 2987-2992.
